Keon Sabb was born and raised in Glassboro, New Jersey. He initially attended Glassboro High School before transferring to nearby Williamstown High School for his junior year then finishing at IMG Academy for his senior season. Sabb played both sides of the ball well and in his sophomore season he collected 31 tackles and five interceptions on defense, and hauled in 29 receptions for 376 yards and six touchdowns. Coming out of high school, Sabb was rated a four-star recruit and had several Division 1 offers. He decided to commit to play for Clemson but eventually flipped his commitment to play for the Michigan Wolverines.
In 2022, Sabb appeared in four games but did not record any statistics. As a sophomore in 2023, Sabb started five games for the Wolverines and recorded 28 tackles, a shared sack and two interceptions, returning one for a touchdown.
After the 2023 season Sabb decided to enter the transfer portal and elected to play for the University of Alabama.