Mike Green attended Lafayette High School in Williamsburg, Virginia, where he played linebacker and tight end. In his senior season, he collected 70 tackles and nine sacks. Green was also on the wrestling team and finished second in the 185-pound tournament in his sophomore season, and third in the 220-pound tournament as a junior. Green was rated a three-star recruit and committed to the University of Virginia.
As a true freshman at Virginia in 2021, Green played in six games and had four tackles and one sack. After not playing any games in 2022, he entered the transfer portal and transferred to Marshall University. In his first year at Marshall in 2023, he had 43 tackles and 4.5 sacks for the Thundering Herd and returned to Marshall as a starter in 2024.
Green took off in 2024 for the Marshall Herd. He started 13 games and collected 84 tackles, 23 tackles for a loss and 17 sacks. Green declared for the NFL draft at the end of the seaons.